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Synthesis,characterization and biological evaluation of m-phenetidine derivatives
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نویسنده
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aziz-ur-rehman department of chemistry ,siddiqa a. ,abbasi m.a. ,rasool s. ,ashraf m. ,ismail t. ,arshad s. ,khalid n. ,khan k.m.
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 1 - صفحه:122 -130
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چکیده
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Summary: the synthesis of compounds bearing sulfamoyl group and amide linkage is pharmacologically important due to their splendid biological activities. in the presented research work n-(3-ethoxyphenyl)-4-methylbenzenesulfonamide (3) was synthesized by the coupling of m-phenetidine (1) with 4-methylbenzenesulfonyl chloride (2) in basic aqueous media. compound 3 on reaction with 2-bromo-n-aryl/aralkyl substituted acetamides,5a-d,synthesized the products,6a-d. the bromination of compound 3 yielded n-(2,4-dibromo-5-ethoxyphenyl)-4-methylbenzenesulfonamide (7) which on further treatment with different electrophiles,8a-d yielded compound 9a-d. enzyme inhibition activities of all the synthesized compounds were evaluated against acetylcholinesterase,butyrylcholinesterase,lipoxygenase,urease,chymotrypsin and tyrosinase enzymes; and found to be the most prominent inhibitor of tyrosinase enzyme. © 2015,chemical society of pakistan. all rights rserved.
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کلیدواژه
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4-Methylbenzenesulfonyl chloride; Anti-enzymatic activity; m-phenetidine
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آدرس
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government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, h.e.j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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