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Synthesis and biological activity evaluation of Schiff bases of 5-acyl-1,2,4-triazine
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نویسنده
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mojzych m. ,sebela m.
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 2 - صفحه:300 -305
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چکیده
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A simple and general method has been developed for the synthesis of various schiff bases (oximes,hydrazones,semicarbazones and thiosemicarbazones) derived from 5-acyl-1,2,4-triazines. some of the new synthesized schiff bases were tested for biological activity but only oximes 2a-c shown poor antiviral activity. the oxime derivatives of 5-acyl-3-methylsulfanyl-1,2,4-triazine were tested with pea-seedling diamine oxidase as the enzyme is known to be inhibited by oxime compounds. however,only weak non-competitive inhibitory effects were observed (ki of 10-2 m). © 2015,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Antiviral activity; Hydrazones of 5-acyl-1 ,4-triazines; Oximes of 5-acyl-1 ,4-triazines; Schiff base; Thiosemicarbazones and semicarbazones of 5-acyl-1 ,4-triazines
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آدرس
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department of chemistry,siedlce university of natural sciences and humanities,3 maja 54, Poland, department of biochemistry,faculty of science,polacky university,slechtitelu 11, Czech Republic
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Authors
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