Synthesis of novel (E)-α-(methoxyimino) benzeneacetate derivatives and their fungicidal activities

In order to find novel strobilurin derivatives with good fungicidal activities,a series of (e)-α-(methoxyimino)benzeneacetate analogues containing 1,2,4-triazole schiff base moiety were designed and synthesized. their structures were confirmed by ir,1h-nmr,hrms or elemental analyses. the antifungal activities indicated that compounds 6 showed moderate to good fungicidal activities against rhizoctonia solani,botrytis cinereapers,fusarium graminearum and blumeria graminis at the concentration 50 μg/ml. for example,compounds 6e and 6h exhibited promising antifungal activity against rhizoctonia solani,botrytis cinereapers and fusarium graminearum. compounds 6g and 6j had higher fungicidal activities against blumeria graminis at the concentration of 50 μg/ml,inhibitory rate is 95.32% and 89.67%,respectively. © 2015,chemical society of pakistan. all rights reserved.