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Antioxidant potential of cyclopeptide alkaloids isolated from Zizyphus oxyphylla
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نویسنده
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kaleem w.a. ,muhammad n. ,khan h. ,rauf a. ,zia-ul-haq m. ,qayum m. ,khan a.z. ,nisar m. ,obaidullah department of pharmacy
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 3 - صفحه:474 -478
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چکیده
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The present study reports on the antioxidant potential of five cyclopeptide alkaloids isolated from zizyphus oxyphylla including oxyphylline-d 1,nummularin-c 2,nummularin-r 3,oxyphylline-b 4,oxyphylline c 5 using dpph free radical assay,nitric oxide radical assay and reducing power assay. the isolated alkaloids demonstrated marked antioxidant potential in a concentration dependent manner. among the tested molecules,the compounds,2 was most potent with ic50 values of 27.23,32.03 and 22.45 μg/ml in dpph free radical assay,nitric oxide radical assay and reducing power assay respectively. © 2015,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Antioxidant activity.; Cyclopeptide alkaloids; Zizyphus oxyphylla
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آدرس
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department of pharmacy,university of sawabi, Pakistan, department of pharmacy,abdul wali khan university, Pakistan, department of pharmacy,abdul wali khan university, Pakistan, institute of chemical sciences,university of peshawar, Pakistan, research institute of pharmaceutical sciences,department of pharmacognosy,university of karachi, Pakistan, department of pharmacy,kohat university of science and technology, Pakistan, department of pharmacy,university of peshawar, Pakistan, department of pharmacy,university of peshawar, Pakistan, university of peshawar, Pakistan
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Authors
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