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N-sulfonated derivatives of 2,3-xylidine as suitable antibacterial agents
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نویسنده
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abbasi m.a. ,sheeza a. ,aziz-ur-rehman department of chemistry ,siddiqui s.z. ,khan k.m. ,malik r. ,ahmad i.
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 3 - صفحه:541 -548
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چکیده
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The objective of the current research effort was to unravel the antibacterial potential of some newly synthesized sulfonamides. 2,3-dimethylaniline (2,3-xylidine,1) was reacted with different sulfonyl chlorides (2a-g) under dynamic control of ph (9-10) in aqueous alkaline medium to generate a series of n-sulfonated derivatives of 2,3-xylidine (3a-g). the plausible structures of the synthesized derivatives were corroborated by contemporary spectral techniques e.g. ir,1h-nmr and eims. moreover,n-sulfonated derivatives were screened against different gram negative and positive bacterial strains to evaluate their inhibitory potential. they depicted good to moderate inhibitory potential,especially,n-(2,3-dimethylphenyl)methanesulfonamide (3a),n-(2,3- dimethylphenyl)-4-methylbenzenesulfonamide (3b),n-(2,3-dimethylphenyl)-4- bromobenzenesulfonamide (3d) and n-(2,3-dimethylphenyl)naphthalene-2-yl-sulfonamide (3f) were amongst the potent inhibitors as compared to standard; ciprofloxacin. © 2015,chemical society of pakistan. all rights reserved.
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کلیدواژه
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3-Dimethylaniline; 1h-NMR; Anti-bacterial Potential; EIMS; N-Sulfonated Derivatives
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آدرس
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department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, government college university, Pakistan, department of chemistry,government college university, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan
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Authors
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