Synthesis,antimicrobial,antioxidant and nematicidal activity of (2E,4E)-5-(Benzo[d] [1,3]dioxol-5yl)penta-2,4-dienamides

The amides of piperic acid have been synthesized via the condensation of piperic acid with amines. the structural characterization was done by ir,1h-nmr,ei-ms and elemental analysis. the amides 3a-3o were evaluated for their biological activity. it has been found that among others the newly synthesized compound 3f,3k,3m,and 3o have great potential against root-knot nematode meloidogyne incognita that usually affect tomato crop. these compounds exhibited 92,96,82 and 95% mortality rate at lethal concentration (lc50) 4.4,3.4,4.5 and 3.5 mg/ml,respectively. conventionally used nematicide furadan was taken as standard. compound 3h,3c and,3j exhibited significant anti-oxidant activities against 1,1-diphenylpicrylhydrazil (dpph) radical with 80,70 and 72% inhibition (ec50 = 625,937 and 937.5 μg/ml),respectively. ascorbic acid was used as standard. when tested for antimicrobial activity 3m was found to be the most active one showing zone of inhibition in the range of 18-30 mm against all tested microbial strains. good biological activities of synthetic amides indicate their ability to behave as a good antimicrobial and nematicidal agent.