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Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones
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نویسنده
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khan s.r. ,ghouri n. ,karim a. ,naz f. ,fakhri m.i. ,perveen s. ,khan k.m. ,taha m. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 5 - صفحه:980 -985
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چکیده
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Substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4h)-ones 1-27 were evaluated for their activity against leishmania major. compounds 1-27 demonstrated in vitro antileishmanial activities with ic50 values between 28.9 - 69.05 μm,as compared to standard drug pentamidine (ic50 = 5.09 ± 0.04 μm). compounds 12 (ic50 = 28.90 ± 1.10 μm),24 (ic50 = 31.4 ± 2.15 μm),13 (ic50 = 35.0 ± 3.18 μm),16 (ic50 = 35.0 ± 3.13 μm),and 25 (ic50 = 35.0 ± 3.18μm) displayed signifiant antileishmanial activities. whereas,compounds 8-10,15,19,and 26 with ic50 values of 62.2 ± 3.36,57.8 ± 2.30,57.72 ± 5.02,56.18 ± 4.40,57.85 ± 2.25,69.05 ± 6.20,54.8 ± 1.50,and 57.8 ± 2.30 μm showed a moderate antileishmanial activities.
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کلیدواژه
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Antileishmail activities; Substituted 2-phenyl-4-[phenylmethylidene]-1 ,3-oxazol-5(4H)-one
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آدرس
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h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, pcsir laboratories complex,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi, Pakistan, atta-ur-rahman institute for natural product discovery,universiti teknologi mara (uitm),puncak alam campus,bandar puncak alam,selangor d. e.,malaysia,faculty of applied science,uitm,shah alam, Malaysia, h.e.j. research institute of chemistry,international centre for chemical and biological sciences,university of karachi,karachi,pakistan,department of biochemistry,faculty of science,king abdulaziz university, Saudi Arabia
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Authors
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