Synthesis of some 1,2,4-triazole derivatives and investigation of their fungicidal activities

The synthesis of a series of 3-pyridyl-6-aryl-s-triazolo (3. 4-b) (1,3. 4) - thiadiazoles are described,synthesis of 3-pyndyl-6-aryl-s-triazolo (3. 4-b) (1,3,4) - thiadiazoles (3a-m) have been achieved by the condensation of potassium dithiocarbazinate (1) with hydrazine hydrate and water. was under reflux 8 hours to yield 4-amino-3-pyridyl-5-mercapto-s-triazole (2). followed bv treatment with aromatic acid the compounds (3a-m) were characterized by spectral and elemental analyses. all thirteen compounds have been assayed for their fungicidal activity against p. oryzae. b. cinerea,a. nigar,c. albicans and t. rubrum. compounds containing aryl substituents at position six and the 1. 2,4-triazole moiety at position one or two showed reasonable fungicidal activity.