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Facile syntheses of bioactive 5-arylidenethiobarbituric acids
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نویسنده
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sharif a. ,ahmed e. ,munawar m.a. ,jabeen s. ,khan m.-u.-a. ,begum r. ,farrukh a. ,ashraf m. ,arshad s. ,afza n.
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منبع
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journal of the chemical society of pakistan - 2011 - دوره : 33 - شماره : 4 - صفحه:578 -586
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چکیده
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A simple and green chemistry route for the preparation of 5-arylidenethiobarbituric acids has been developed by knoevenagel condensation of thiobarbituric acid with different aromatic and heteroaromatic aldehydes using catalytic amount of acetic acid by grinding in mortar and pestle. the title compounds were obtained in good to high yields (50-89%) and characterized by ir,nmr,mass spectroscopy and elemental analysis. all compounds exhibited dpph radical scavenging and antibacterial activities,respectively.
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آدرس
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institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, institute of chemistry,university of the punjab,quaid-i-azam campus,lahore, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, college of conventional medicine,faculty of pharmacy and alternative medicine,islamia university of bahawalpur, Pakistan, pharmaceutical research center,pcsir karachi laboratories complex, Pakistan
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Authors
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