Synthesis of substituted pyrimidin-4(1H)-one (uracil) derivatives and some of their reactions

In this paper i described two practical routes for the synthesis of substituted uracilderivatives and achieved some of their reactions. in the first synthesis which is based on the condensation reaction of ethyl 2- cyanoacetate and thiourea,the cyclized compound 6-amino-2- mercaptopyrimidin-4(3h)-one (i) achieved in the presence of sodium ethanoate. thecompund (i) react with 2-(chloromethyl)oxirane in the given medium (ii) was produced,then treated in medium of ethanol in peresence of koh which new recyclized product 8-amino-3,4-dihydro-3- hydroxypyrimido[2,1-b][1,3]thiazin-6(2h)-one (iii) was obtained.the other ring closing cyclization proceeded 6-methyl-2,3-dihydro-2- thioxopyrimidin-4(1h)-one (iv) by ethyl acetoacetate and thiourea in ethyl alcohol and potassium hydroxide medium. in the next reaction,firstly sodium salt of (v) was gained,then it was reacted with 2-(chloromethyl)oxirane. at the end,substitued derivative (vi) was resulted.all synthesized products were confirmed by ir,1h nmr,13c nmr,and elemental analysis. all the experimental data is described extensively in this report.