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   Screening for bioactive compounds from Adiantum capillus-veneris L.  
   
نویسنده yuan q. ,wang j. ,ruan j.
منبع journal of the chemical society of pakistan - 2012 - دوره : 34 - شماره : 1 - صفحه:207 -216
چکیده    The aim of the present study was to assess the biological properties of a. capillus-veneris l. and identified the functional compounds in plant extracts. the antimicrobial activities were determined with broth dilution method using 4 gram-positive bacteria,2 gram-negative bacteria and 1 fungus. the antioxidant activities were studied by employing various in vitro antioxidant assays such as dpph • and abts scavenging and fe 3+-fe 2+ transformation method. mtt colori metric analysis was used to measure the cytocide rate on sgc-7901 cell line. the content of total phenolics,tannins and flavones were measured by folin-ciocalteu reagent and aluminum nitrate methods,respectively. phytochemical compounds were analyzed by hplc-dad-ms/ms technique. etoac fraction exhibited broad spectrum antimicrobial activities against all tested microorganism especially against candida albicans with the mic of 0.95 μg/ml. similarly,this fraction also exhibited the strongest antioxidant potential among tested samples. the preliminary phytochemical investigation showed that the etoac fraction possessed a highest total flavones,total phenolics contents (21.65 and 42.11% respectively) and seven major compounds of the etoac fraction were characterized by hplc-dad-ms/ms techniques. 3-p-coumaroylquinic acid and kaempferol 3-o-glucoside were the main compounds. the results indicate the possibility that the observed bioactivities are partly contributed by phenolic acids and flavonoids especially by the compounds of 3-p-coumaroylquinic acid and kaempferol 3-o-glucoside.
کلیدواژه Adiantum capillus-veneris; Antimicrobial; Antioxidant; Cytotoxicity; HPLC-DAD-MS/MS
آدرس key laboratory of natural medicinal chemistry and resource evaluation of hubei province,college of pharmacy,tongji medical center of huazhong university of science and technology, China, key laboratory of natural medicinal chemistry and resource evaluation of hubei province,college of pharmacy,tongji medical center of huazhong university of science and technology, China, key laboratory of natural medicinal chemistry and resource evaluation of hubei province,college of pharmacy,tongji medical center of huazhong university of science and technology, China
 
     
   
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