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Synthesis and antibacterial activity of oxime ester derivatives containing 16-isopropyl-5,9-dimethyl tetracyclo [10.2.2.0 1,10.0 4,9] hexadec-15-ene-5,14- dicarboxyl group
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نویسنده
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li j. ,rao x. ,shang s. ,gao y. ,song b.
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منبع
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journal of the chemical society of pakistan - 2012 - دوره : 34 - شماره : 1 - صفحه:217 -222
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چکیده
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Acrylpimaric acid (16-isopropyl-5,9- dimethyltetracyclo [10. 2. 2. 0 1,10.0 4,9]hexadec- 15-ene-5,14-dicarboxylic acid) was prepared by rosin through diels-alder addition reaction,then a series of oxime ester derivatives containing acrylpimaryl (16-isopropyl-5,9-dimethyltetracyclo [10.2.2.0 1,10.0 4,9]hexadec-15-ene-5,14-dicarboxyl) group were synthesized. their structures were characterized by ir,1hnmr,ms,and elemental analysis. the antibacterial activity of these newly synthesized oxime ester derivatives against gram-negative bacteria and gram-positive bacteria were also investigated. the results indicate that compounds display extensive anti-bacterial activity against gram-negative bacteria and gram-positive bacteria. especially compounds (4c,4d,4f,4h and 4k) exhibit excellent anti-bacterial activity against escherichia coli (gram-negative bacteria). compared with the diameter of inhibition zone is 9.66mm of the standard compound bromogeramine,which the diameter of inhibition zone is 12.17mm,10.00mm,10.33mm,9.67mm and 9.67mm respectively.
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آدرس
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institute of chemical industry of forestry products,caf,key lab. of biomass energy and material,jiangsu province,nanjing 210042,china,institute of chemical industry of forestry products,national engineering lab. for biomass chemical utilization,nanjing 210042,china,institute of chemical industry of forestry products,key and lab. on forest chemical engineering,sfa, China, institute of chemical industry of forestry products,caf,key lab. of biomass energy and material,jiangsu province,nanjing 210042,china,institute of chemical industry of forestry products,national engineering lab. for biomass chemical utilization,nanjing 210042,china,institute of chemical industry of forestry products,key and lab. on forest chemical engineering,sfa,nanjing 210042,china,institute of forest new technology,caf, China, institute of chemical industry of forestry products,caf,key lab. of biomass energy and material,jiangsu province,nanjing 210042,china,institute of chemical industry of forestry products,national engineering lab. for biomass chemical utilization,nanjing 210042,china,institute of chemical industry of forestry products,key and lab. on forest chemical engineering,sfa,nanjing 210042,china,institute of forest new technology,caf, China, institute of chemical industry of forestry products,caf,key lab. of biomass energy and material,jiangsu province,nanjing 210042,china,institute of chemical industry of forestry products,national engineering lab. for biomass chemical utilization,nanjing 210042,china,institute of chemical industry of forestry products,key and lab. on forest chemical engineering,sfa, China, institute of chemical industry of forestry products,caf,key lab. of biomass energy and material,jiangsu province,nanjing 210042,china,institute of chemical industry of forestry products,national engineering lab. for biomass chemical utilization,nanjing 210042,china,institute of chemical industry of forestry products,key and lab. on forest chemical engineering,sfa, China
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Authors
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