Production,regulation and transportation of bacillibactin in bacillus subtilis

Bacillus subtilis produces a catecholate type siderophore bacillibactin. this review focuses on the non-ribosomal synthesis,transport and regulation of bacillibactin. bacillibactin biosynthetic operon contains five genes (dhbacebf). the uptake of bacillibactin requires the feuabc transporter,innermembrane permease,fepdg and yusv atpase and an esterase encoding gene,besa and while export required ymfe major facilitator super-family (mfs)-type transporter. fur is the major iron-controlled transcriptional regulator in b. subtilis,which acts as an iron-dependent repressor of the dhb operon in vivo while an iron-independent repressor in vitro. knowledge of the fur regulon will be useful in interpreting other global analysis of transcriptional responses.