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Immunomodulatory studies of methyl 4-hydroxybanzoate isolated from vitex agnus-castus
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نویسنده
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azizuddin department of chemistry ,mesaik m.a. ,choudhary m.i. ,khan k.m. ,tareen r.b.
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منبع
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journal of the chemical society of pakistan - 2012 - دوره : 34 - شماره : 4 - صفحه:971 -975
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چکیده
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Vitex agnus-castus linn. (verbenaceae) is locally known as hub-el-faked and sumbhalu-ke-bij. it is abundantly found in baluchistan (pakistan) and extensively used for medicinal purpose. methyl 4-hydroxybenzoate (1) is a very well known compound,was isolated from the aerial parts of vitex agnus-castus. methyl 4-hydroxybenzoate (1) was found to be a moderate immunomodulatory and non-cytotoxic activities. the activity was tested in vitro for chemiluminescence,chemotaxis,t-cell proliferation and cytotoxicity. methyl 4-hydroxybenzoate (1) exhibited a moderate inhibitory effect on oxidative burst of neutrophils in a dose dependent manner. it was found to have a moderate suppressive effect on the chemotaxic action at lower concentrations on fmlp (10 -8 m) stimulated neutrophils. it also showed a suppressive effect on pha stimulated t-cell (pmbc).
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آدرس
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federal urdu university of arts,science and technology,gulshan-e-iqbal campus, Pakistan, international center for chemical and biological sciences,h.e.j. research institute of chemistry,university of karachi, Pakistan, international center for chemical and biological sciences,h.e.j. research institute of chemistry,university of karachi, Pakistan, international center for chemical and biological sciences,h.e.j. research institute of chemistry,university of karachi, Pakistan, department of botany,baluchistan university, Pakistan
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Authors
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