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Development and validation of a spectrophotometric method for the determination of entecavir in pure and tablet dosage form
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نویسنده
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shabbir h.m.n. ,hayat m.m. ,ashraf m. ,nasim f.-u.-h. ,ahmad i. ,uzair m. ,haque n.
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منبع
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journal of the chemical society of pakistan - 2012 - دوره : 34 - شماره : 6 - صفحه:1605 -1608
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چکیده
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A direct spectrophotometric method for the determination of entecavir is developed. entecavir is a guanine analogue that is used in the treatment of hepatitis b. the absorbance of the pure drug was measured at wavelength 253 nm. the method was found linear from 2.5-40 μg ml-1 (r2,0.999). the rsd was 1.1% and accuracy was 99%. the validation results and statistical data demonstrate that the method is reliable,simple,cost effective and reproducible and has an importance in quality assurance of entecavir analysis.
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کلیدواژه
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Entecavir; Spectrophotometer; Tablet dosage form
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آدرس
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department of pharmacy,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, department of chemistry,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, faculty of pharmacy,b.z. university, Pakistan, department of pharmacy,university of balochistan,quetta, Pakistan
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Authors
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