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Development of direct reversed-phase high performance liquid chromatographic method for quantitative determination of gabapentin in pharmaceutical dosage
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نویسنده
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hassan w. ,zaman b. ,rahman s. ,rahman a.u. ,ali n. ,mohammadzai i.u.
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منبع
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journal of the chemical society of pakistan - 2012 - دوره : 34 - شماره : 6 - صفحه:1477 -1481
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چکیده
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The objective of the present work was to develop and validate a rapid analytical method for quantitative determination of gabapentin in pharmaceutical dosage tablets and capsules. an accurate,simple,and sensitive reversed-phase high performance liquid chromatographic (hplc) method,uv detection at 215 nm and flow rate at 1.0 ml/min has been developed. isocratic elution was used instead of gradient elution to reduce the time and cost of serial analysis. the mobile phase was a mixture of water and methanol (hplc grade). the retention time (rt) of gabapentin was 4.681 ± 0.013 minutes. recovery,precision,accuracy,and linearity were determined for the stated method. the calibration curve was linear and the correlation coefficient was 0.9996. there was no chromatographic interference from other excipients present in dosage form. the method was validated appropriately and successfully used for determination of gabapentin in pharmaceutical formulations.
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کلیدواژه
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Dosage form; Gabapentin; HPLC; UV detection
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آدرس
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institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan, institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan, institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan, institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan, institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan, institute of chemical sciences,university of peshawar,peshawar -25120, Pakistan
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Authors
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