Mixture pseudo-chromatographic separation by matrix-assisted diffusion ordered spectroscopy

Pseudo-separation for phenylalanine (phe),ibuprofen (ibu),capsaicin (cap) and norfloxacin (nor) were studied by sodium dodecyl sulfate (sds) or hydroxypropyl-β-cyclodextrin (hpβcd) assisted diffusion ordered spectroscopy (dosy). stokes-einstein equation shows a linear relationship between the logarithms of apparent diffusion coefficients and logarithms of molecular weight (mw). however,with matrix added,block factors became the important factors than molecular weight. pseudo-separation was improved by sds or hpβcd assist. research showed different separation mechanism for sds and hpβcd-assisted dosy. the former used different lipo-hydro partition coefficient,and the latter used complexing mechanism.