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Trypsin inhibitory activity of artemisinin and its biotransformed product
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نویسنده
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shahwar d. ,raza m.a. ,ahmad v.u.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 1 - صفحه:135 -138
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چکیده
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Artemisinin (1),a sesquiterpene lactone is an important constituent of anti-malarial drugs. in the present study,it was extracted from aerial parts of artemisia roxburghiana besser. biotransformation of artemisinin (1) was carried out in the culture of aspergillus niger gc-4 which yielded 5-hydroxy artemisinin (2) the structures of 1-2 were confirmed through spectral studies. both compounds were screened against trypsin using colorimetric method. the biotransformed product 2 showed significant protease inhibitory activity with 53.5 ± 1.6% inhibition and ic50 = 0.29 ± 0.02 mm as compared to artemisinin (20.4 ± 0.3% inhibition).
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آدرس
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research lab. ii,department of chemistry,government college university, Pakistan, research lab. ii,department of chemistry,government college university,lahore-54000,pakistan,department of chemistry,hafiz hayat campus,university of gujrat, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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