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Concentration of 188re-perrhenate for therapeutic radiopharmaceuticals
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نویسنده
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bokhari t.h. ,hina s. ,ahmad m. ,iqbal m. ,shafiq m. ,arshad m.n. ,asghar m.n. ,aslam m. ,mansha a. ,qadir m.i. ,khan i.a.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 1 - صفحه:147 -150
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چکیده
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Rhenium-188 (t1/2=16.9h) has great potential for a variety of therapeutic applications,including radionuclide synovectomy,oncology and bone pain palliation. the radioactive concentration of 188re is dependent upon the specific activity of 188w,which dictates the bed size of the alumina/gel column. due to the high content of inactive tungsten in neutron irradiated wo3,large columns containing aluminum oxide or gel are needed to prepare to double neutron capture based 188w/ 188re generators that results in large elution volumes containing relatively high188w contents and low concentrations of 188reo4 -. this decrease in specific volume of 188reo4 - places a limitation because a high radioactive concentration of 188reo4 - is always needed for filling angioplasty balloons or other therapeutic radiopharmaceuticals like 188re -ehdp 188re -edtmp,188re -mag 3 and 188re -dtpa. we report post elution concentration of 188reo4 - using in- house prepared lead cation exchange and alumina columns. using these columns high bolus volume (10 ml saline) of 188reo4 - can conveniently be concentrated in 1 ml of physiological saline for therapeutic use.
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کلیدواژه
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188W/188Re generator; Concentration of 188reperrhenate; Isotonic saline as eluent; Lead (Pb) cation exchange column; Tiny alumina column
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آدرس
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department of chemistry,government college university, Pakistan, department of bioinformatics and biotechnology,government college university, Pakistan, isotope production division,pakistan institute of nuclear science and technology, Pakistan, department of chemistry and biochemistry,university of agriculture, Pakistan, department of chemistry,government college university, Pakistan, chemistry department and centre of excellence for advanced materials research, Saudi Arabia, department of chemistry,forman christian college university, Pakistan, pharmaceutical research centre,pcsir labs complex, Pakistan, department of chemistry,government college university, Pakistan, college of pharmacy, Pakistan, department of physics,government college university, Pakistan
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Authors
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