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Bioactive secondary metabolites of the fungus Noduliosporium sp. isolated from Dittrichia viscosa
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نویسنده
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nazir m. ,riaz n. ,ashraf m. ,ejaz s.a. ,saleem m. ,ahmad i. ,hussain h. ,schulz b. ,draeger s. ,jabbar a. ,krohn k.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 2 - صفحه:463 -467
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چکیده
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The culture extract of the fungus nodulisporium sp. # 9897,on chromatographic purification yielded 16-hydroxyisopimar-7-en-18-oic acid: nodulerterpene (1) along with cytochalasine c (2),d (3),canabiside b (4),ergosterol (5),24-methylcholesta-7,22-e-diene-3β,5α- diol-6-one (6),(24r)-24-methyl-5α-cholest-7-ene-3β,5,6β-triol (7) and uracil (8). the structures of all the compounds were established with the help of spectroscopic analysis including 1d,2d nmr data and high resolution mass spectrometry and or in comparison with the published literature. the isolates 1-4 showed mild activity against tested gram positive and gram negative pathogens. nodulerterpene (1) also exhibited weak inhibitory activity against acetylcholinestrase (ache),butrylcholinestrase (bche) and lipoxegenase (lox).
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آدرس
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department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur,63100, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur,63100, Pakistan, department of biochemistry and biotechnology,baghdad-ul-jadeed campus,islamia university of bahawalpur-63100, Pakistan, department of pharmacy,faculty of pharmacy,railway road campus,63100, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur,63100, Pakistan, department of chemistry,university of paderborn,warburger strasse 100, Germany, department of chemistry,university of paderborn,warburger strasse 100, Germany, institute of microbiology,university of braunschweig,spielmannstraße 7,31806, Germany, institute of microbiology,university of braunschweig,spielmannstraße 7,31806, Germany, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur,63100, Pakistan, department of chemistry,university of paderborn,warburger strasse 100, Germany
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Authors
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