Synthesis,characterization and biological screening of various O-phenyl-N-aryl carbamates

A series of o-phenyl-n-aryl carbamates (3a-i) were synthesized by the reaction of phenyl chloroformate (1) with different aromatic amines (2a-i). the compounds were characterized by ir and 1h-nmr and screened against acetylcholinesterase,butrylcholinesterase and lipoxygenase enzymes. the results revealed that o-phenyl-n-phenyl carbamate (3a) and o-phenyl-n-(3-hydroxyphenyl) carbamate (3e) were active against acetylcholinesterase while o-phenyl-n-benzyl carbamate (3b),o-phenyl-n-(4-hydroxyphenyl) carbamate (3f) and o-phenyl-n-(3-methoxyphenyl) carbamate (3h) exhibited potential inhibitory activity against 5-lipoxygenase. all these carbamates were also assayed for their antimicrobial and hemolytic activities. o-phenyl-n-(2-hydroxyphenyl) carbamate (3d),o-phenyl-n-(4-hydroxyphenyl) carbamate (3f) and o-phenyl-n-(3-methoxyphenyl) carbamate (3h) showed good antimicrobial and hemolytic activity among all the carbamates.