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Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives
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نویسنده
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khan k.m. ,khan m. ,karim a. ,taha m. ,ambreen n. ,gojayev a. ,perveen s. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 2 - صفحه:495 -498
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چکیده
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N,n'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (xo) inhibitory activity. majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (ic50 = 20.97 ± 0.29 - 327.0 ± 3.50 μm),while eight compounds were found to be completely inactive. a structure-activity relationship has been discussed,identifying structural features,responsible for varying degree of activity.
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کلیدواژه
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Antioxidants; Gout; N ,N'-dimethylbarbituric acid derivatives; Xanthine oxidase inhibition
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,department of chemistry,abdul wali khan university,mardan-23200, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,atta-ur-rahman institute for natural product discovery,universiti teknologi mara (uitm),puncak alam campus,42300 bandar puncak alam, Malaysia, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,baku state university,z. khalilov street 23,az 1148, Azerbaijan, pcsir laboratories complex,karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan
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Authors
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