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Superoxide respiratory burst inhibitory activity of bis-schiff bases of Isatins
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نویسنده
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khan k.m. ,khan m. ,ali m. ,qadir m.i. ,perveen s. ,karim a. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:987 -993
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چکیده
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Bis-schiff bases 1-27 were synthesized and evaluated for their anti-inflammatory activity and possible cytotoxicity. compounds 1-27 showed a varying degree of respiratory burst inhibitory activity with ic50 values between 242.97 - 652.12 μm. compound 4 (ic50 = 242.97 ± 2.24 μm) showed an excellent activity,when compared with standard indomethacine (ic50 = 271.12 ± 1.12 μm). compounds 9,16,18,19,24,and 26 showed varying degree of activity,while remaining compounds were found to be inactive.
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کلیدواژه
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Anti-inflammatory activity; Bis-Schiff bases; Cytotoxicity; Immunomodulating activity; Isatins; Respiratory burst inhibition
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,department of chemistry,abdul wali khan university, Pakistan, department of chemistry,comsats institute of information technology,university road, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, pcsir laboratories complex,karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,department of biochemistry,faculty of science,king abdulaziz university, Saudi Arabia
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Authors
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