Comparative study of fluoride concentration in human serum and drinking water in fluorinated endemic and non endemic areas of Pakistan

For comparing the human blood serum and drinking water fluoride levels of subjects with dental fluorosis and bony deformities,this study is carried out with individuals ranging 8-17 age group fluorinated sham ki bhatiyan,punjab (endemic) and queens road,lahore,punjab (nonendemic) areas. fluoride concentrations were determined using ion selective electrode methodology and statistically compared. both the groups showed a significant difference (p < 0.05). subjects from fluorotic area showed high concentration of fluoride in water and blood serum samples (mean value: 135.587±77.435 and 2.765±0.469 μmoll-1 in water and blood serum samples respectively) as compared to controls (mean value: 19.509±2.432 and 2.364± 0.667 μmoll -1). these findings indicate that serum and water fluoride concentrations have a significant positive dose response relationship with the prevalence of dental fluorosis in an area associated with high fluoride level in drinking water.