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Synthesis of acyl analogues of coniferyl alcohol and their antimycobacterial activity
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نویسنده
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bhatti h.a. ,uddin n. ,begum s. ,siddiqui b.s.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:886 -889
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چکیده
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In search of new anti-mycobacterial agents seven acyl and one benzyl derivatives of coniferyl alcohol were synthesized and evaluated along with coniferyl alcohol for antitubercular activity against mycobacterium tuberculosis h37rv (mtb) in vitro. four compounds (3-6) showed greater activity than the parent compound and inhibited mtb with ic90 9.11,8.92,4.28 and 3.01 μg/ml respectively. compound 6,the most potent compound in vitro exhibited cc 50 10.216 μg/ml in vero cells with selectivity index 3.394. reference compounds used were rifampin and isoniazid and had ic90 0.0031 and 0.063 μg/ml respectively.
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کلیدواژه
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Acyl and benzyl derivatives; Antitubercular activity; Coniferyl alcohol; Mycobacterium tuberculosis H37Rv
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آدرس
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hej research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,comsats institute of information technology, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,center of excellence in marine biology,university of karachi, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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