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Launeugenol,a new eugenol derived dimer from launaea intybacea
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نویسنده
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saleem m. ,parveen s. ,riaz n. ,ashraf m. ,ejaz s.a. ,waris h.m. ,ali m.s. ,malik a. ,jabbar a.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:911 -915
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چکیده
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A eugenol derived dimer (1) has been isolated from the methanolic extract of the whole plant of launaea intybacea along with the three known compounds. the structures of all the isolates (1-4) were established using 1d ( 1h,13c) and 2d nmr (hmqc,hmbc,cosy) spectroscopy,mass spectrometry and comparison with the reported data in the literature. compound 1 was tested for its dpph radical scavenging and enzyme inhibitory activities against enzyme acetylcholinesterase (ache),butyrylcholinesterase (bche) and lipoxygenase (lox) and found to be moderately active against enzyme lipoxygenase with ic50 value of 56.3 μm.
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کلیدواژه
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Compositae; Enzyme inhibition; Launaea intybacea; Secondary metabolite
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آدرس
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department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur 63100, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur 63100, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur 63100, Pakistan, department of biochemistry and biotechnology (bbt),baghdad-ul-jadeed campus,islamia university of bahawalpur-63100, Pakistan, department of pharmacy,khawaja fareed campus,islamia university of bahawalpur,63100, Pakistan, cholistan institute for desert studies (cids),baghdad-ul-jadeed campus,islamia university of bahawalpur,63100, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences (iccbs),university of karachi,75270, Pakistan, hej research institute of chemistry,international center for chemical and biological sciences (iccbs),university of karachi,75270, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur 63100, Pakistan
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Authors
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