Synthesis and anti-anaphylactic activity of 7-azaindole derivatives

As a part of our program to discover novel analogue of 7-azaindole (1h-pyrrolo [2,3-b] pyridine) having useful biological activities,some derivatives have been synthesized and evaluated for their anti-anaphylactic activity. the synthesized compounds 6a and 8a showed significant activity. other compounds exhibited negative results. in the bio-screening of the compounds for antianaphylactic inhibition. compounds 6a and 8a (ethyl phenacyl derivative) were found most active. compounds a1-a5 and a7 containing different groups displayed no inhibition. the result indicates that methyl substitution in phenacyl chain at different position (c-1' for compound 6a and c-2' for compound 8a) is making significant change in the activity.