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Synthesis and anti-anaphylactic activity of 7-azaindole derivatives
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نویسنده
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saify z.s. ,sultana n. ,walker j. ,zareen t. ,rafiq k.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:966 -971
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چکیده
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As a part of our program to discover novel analogue of 7-azaindole (1h-pyrrolo [2,3-b] pyridine) having useful biological activities,some derivatives have been synthesized and evaluated for their anti-anaphylactic activity. the synthesized compounds 6a and 8a showed significant activity. other compounds exhibited negative results. in the bio-screening of the compounds for antianaphylactic inhibition. compounds 6a and 8a (ethyl phenacyl derivative) were found most active. compounds a1-a5 and a7 containing different groups displayed no inhibition. the result indicates that methyl substitution in phenacyl chain at different position (c-1' for compound 6a and c-2' for compound 8a) is making significant change in the activity.
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کلیدواژه
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7-azaindole (1H-Pyrrolo [2 ,3-b] pyridine); Anti-anaphylactic activity; Synthesis
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آدرس
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international center for chemical sciences,h. e. j. research institute of chemistry,university of karachi, Pakistan, pharmaceutical research center,pcsir laboratories complex, Pakistan, dept of pharmacy, United Kingdom, international center for chemical sciences,h. e. j. research institute of chemistry,university of karachi, Pakistan, international center for chemical sciences,h. e. j. research institute of chemistry,university of karachi, Pakistan
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Authors
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