Synthesis and in vitro antibacterial and antifungal activities of benzoxazole derivatives

The in vitro antibacterial and antifungal activities of twenty-nine (29) benzoxazole derivatives were tested against fifteen gram-positive and sixteen gram-negative strains. out of the twenty-nine compounds,eighteen compounds 3-5,7-9,11-13,15-25 showed a broad range of activity against tested gram-positive microorganisms,whereas rest of the compounds 6,10,14 and 26-31 were found to be completely inactive against all the tested strains of gram-positive bacteria. five compounds 8,11-13,and 15 showed activities against gram-negative strains whereas the rest were devoid of any activity. twenty-one (21) out of twenty-nine (29) compounds possessed antifungal activity. the structures of the synthetic compounds were confirmed by ir,eims and 1hnmr spectral data.