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Benzimidazoles: A new class of carbonic anhydrase inhibitors
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نویسنده
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khan k.m. ,khan m. ,saleem m. ,taha m. ,perveen s. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:901 -904
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چکیده
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Carbonic anhydrase inhibitory activity of benzimidazole derivatives 1-24 has been evaluated. compounds 22 (ic50 = 7.47 ± 0.39 μm),21 (ic50 = 10.31 ± 0.11 μm),20 (ic50 = 23.1 ± 1.78 μm),12 (ic50 = 12.16 ± 0.10 μm),11 (ic50 = 12. 81 ± 0.29 μm),and 15 (ic50 = 13.18 ± 0.37 μm) showed carbonic anhydrase inhibitory activity,and compared with the standard acetozolamide (ic50 = 0.31 ± 0.0006 μm). all the compounds were characterized by spectroscopic techniques.
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کلیدواژه
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Aromatic aldehydes; Benzimidazole; Carbonic anhydrase inhibition; Phenylenediamine
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,department of chemistry,abdul wali khan university, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,atta-ur-rahman institute for natural product discovery,universiti teknologi mara (uitm),puncak alam campus,42300 bandar puncak alam, Malaysia, pcsir laboratories complex karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university karachi,karachi-75270,pakistan,department of biochemistry,faculty of science,king abdulaziz university, Saudi Arabia
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Authors
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