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Oligocephlate,a new α-glucosidase inhibitory neohopane triterpene from Vernonia oligocephala
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نویسنده
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riaz n. ,feroze k. ,saleem m. ,musaddiq s. ,ashraf m. ,alam u. ,mustafa r. ,jabeen b. ,ahmad i. ,jabbar a.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:972 -975
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چکیده
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Oligocephlate (1),a new neohopane triterpene together with β-sitosterol (2),lupeol (3),oleanolic acid (4) and β-sitosterol-3-o- β-d-glucopyranoside (5) were isolated from the n-hexane soluble fraction of the methanolic extract of the whole plant of vernonia oligocephala. the structures of these compounds (1-5) were established by using 1d nmr ( 1h and 13c) and 2d nmr (hmqc,hmbc,cosy,noesy) spectroscopy and mass spectrometry (eims,hreims). compound 1 showed inhibitory activity against enzyme α-glucosidase with ic50 value 18.5 μm.
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کلیدواژه
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α-glucosidase Inhibition; Asteraceae; Secondary metabolite; Triterpene; Vernonia oligocephala
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آدرس
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department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of biochemistry and biotechnology,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of biochemistry and biotechnology,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan, department of pharmacy,khawaja fareed campus,islamia university bahawalpur, Pakistan, department of chemistry,baghdad-ul-jadeed campus,islamia university of bahawalpur, Pakistan
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Authors
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