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Acylhydrazide schiff bases: Synthesis and antiglycation activity
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نویسنده
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khan k.m. ,taha m. ,rahim f. ,fakhri m.i. ,jamil w. ,khan m. ,rasheed s. ,karim a. ,perveen s. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 3 - صفحه:929 -937
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چکیده
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Acylhydrazide schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. compounds 16 (ic50 = 199.82 ± 10.6 μm),27 (ic50 = 234.83 ± 10.28 μm),2 (ic50 = 240.99 ± 4.2 μm),and 14 (ic50 = 276.2 ± 2.3 μm) showed antiglycation potential comparable to the standard rutin (ic50 = 294.50 ± 1.5 μm). from this study we identified a new series of potent antiglycating agents. a structure-activity relationship has been described,while all compounds were characterized by using different spectroscopic techniques.
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کلیدواژه
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Acylhydrazide Schiff bases; AGEs; Antiglycation
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,atta-ur-rahman institute for natural product discovery,universiti teknologi mara (uitm),puncak alam campus,42300 bandar puncak alam, Malaysia, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,department of chemistry,hazara university, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,institute of advance research studies in chemical sciences, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,department of chemistry,abdul wali khan university,mardan-23200, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, pcsir laboratories complex,karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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