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Synthesis of N-substituted derivatives of N-(4-(N-(5-Chloro-2 methoxyphenyl)sulfamoyl)phenyl)acetamide with potential antiurease activity
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نویسنده
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aziz-ur-rehman department of chemistry ,ayoub m. ,abbasi m.a. ,gul s. ,ashraf m. ,hassan r. ,ahmad i. ,khan k.m.
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منبع
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journal of the chemical society of pakistan - 2013 - دوره : 35 - شماره : 6 - صفحه:1516 -1521
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چکیده
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In this study,a new series of n-alkyl/arakyl derivatives of n-(4-(n-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (5a-k) was synthesized and screened for enzyme inhibition activity. target compounds,n-alkyl/arakyl sulfamoylacetamides (5a-k) were synthesized by stirring n-(4-(n-(5-chloro-2-methoxyphenyl)sulfamoyl)phenyl)acetamide (3) with different electrophiles (4a-k) in the presence of sodium hydride (nah) and n,n-dimethylformamide (dmf). the structures of all the synthesized compounds have been deduced from their spectral (1h-nmr,ir,ei-ms) data. all the new compounds displayed antiurease activity to varying degree.
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کلیدواژه
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1H-NMR; 2-amino-4-chloroanisol; 4-acetamidobenzenesulfonyl chloride; EI-MS; IR; Urease
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آدرس
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government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, h.e.j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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