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5-Arylidene N,N-dimethylbarbiturates as urease inhibitors
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نویسنده
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khan k.m. ,khan m. ,khan a. ,perveen s. ,naz f. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2014 - دوره : 36 - شماره : 3 - صفحه:524 -527
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چکیده
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Earlier 5-arylidene n,n-dimethylbarbiturates 1-24 were reported by our group as novel antioxidant,nevertheless,urease inhibitory activity of these compounds has not been investigated at all. in the present study,compounds 1-24 were synthesized by the reaction of n,n-dimethylbarbituric acid with different aromatic aldehydes,and screened for their in vitro urease inhibitory effects. compound 7,was found to be most active urease inhibitor in the series. nonetheless,compounds 11,12,and 19 were also active against urease enzyme.
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کلیدواژه
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5-Arylidene N; N-dimethylbarbiturates; Thiourea; Urease inhibition
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi-75270,pakistan,department of chemistry,abdul wali khan university, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, pcsir laboratories complex karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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