N-substituted derivatives of 5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl-2- sulfanyl acetamide as valuable bioactive compounds

In the described research work,a new series of n-substituted derivatives of 5-(4- chlorophenyl)-1,3,4-oxadiazol-2-yl-2-sulfanyl acetamide has been synthesized. the synthesis was carried out by converting 4-chlorobenzoic acid (1) into ethyl 4-chlorobenzoate (2),4- chlorobenzohydrazide (3) and then 5-(4-chlorophenyl)-1,3,4-oxadiazol-2-thiol (4) respectively. the target molecules 6a-o were synthesized by reacting compound 4 with different n-alkyl/aryl substituted 2-bromoacetamide (5a-o) in equimolar ratios of using dmf and sodium hydride (nah). the structure of all the synthesized compounds was confirmed by spectral data like ei-ms,ir and 1h-nmr. the compounds were also analysed for antimicrobial & hemolytic activity and most of them were found active against the selected microbial species at variable extent relative to reference standards. but 6f and 6o were the active against the selected panel of microbes and former was most potent one. this series revealed less toxicity and may consider for further biological screening and application trial except 6g and 6j,exhibiting high cytotoxicity.