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Biological screening and chemical constituents of Viburnum grandiflorum
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نویسنده
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shah z. ,ali f. ,ullah h. ,shah a. ,khan d. ,khan s. ,khan r. ,ali i.
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منبع
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journal of the chemical society of pakistan - 2014 - دوره : 36 - شماره : 1 - صفحه:113 -118
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چکیده
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Extensive chromatographic separation and purification of the chloroform soluble fraction of the anti-malarial plant,viburnum grandiflorum afforded six known compounds namely,3-hydroxy-4,7-megastigmadiene-9-one (1),β-sitosterol (2),awabukinol (3),1-oxo-erythrodiol (4),lupeol (5) and 10-acetylpatrinoside (6). the structures of these compounds were determined by spectroscopic and available data in literature. compounds 6 showed strong inhibition against both of j. b. urease and b. p. urease with ic50 values of 10.45 and 8.65 respectively while compounds 4 and 6 showed strong antimicrobial activities against various pathogenic bacteria and fungi.
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کلیدواژه
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Antimicrobial effect; Chemical constituents; Chloroform soluble fraction; Cytotoxic activity; J. B. urease and B. P. urease inhibition; Viburnum grandiflorum
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آدرس
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department of chemistry,gomal university,dera ismail khan,27100,pakistan,department of chemistry,university of science and technology of china,hefei,anhui, China, department of chemistry,shaheed benazir bhutto university,sheringal, Pakistan, department of biotechnology,university of science and technology,bannu, Pakistan, department of botany,university of science and technology,bannu, Pakistan, department of chemistry,gomal university,dera ismail khan, Pakistan, department of chemistry,gomal university,dera ismail khan, Pakistan, institute of chemical sciences,university of peshawar, Pakistan, department of chemistry,gomal university,dera ismail khan, Pakistan
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Authors
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