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Crystal structure and DNA-binding study of a monoclinic polymorph of N,N′-bis(2-pyridyl)oxamide
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نویسنده
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zhang w.-j. ,wang f. ,zhang k.
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منبع
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journal of the chemical society of pakistan - 2014 - دوره : 36 - شماره : 4 - صفحه:712 -716
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چکیده
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A monoclinic polymorph of n,n′-bis(2-pyridyl)oxamide has been synthesized and characterized by single-crystal x-ray diffract ion method. it crystallizes in monoclinic,space group c2/c with crystallographic data: a = 10.596(3) a˚,b = 12.950(3) a˚,c = 8.612(2) a˚,β = 90.935(8)° and z = 4. in the polymorph,two-dimensional network is formed by hydrogen bond and π-π stacking interact ion. the binding studies of the compound with calf thymus dna (ct-dna) have also been explored by elect ronic absorpt ion t it rat ion and fluorescence quenching experiments,and the results suggest that the compound binds to ct-dna through groove binding.
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کلیدواژه
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Crystal structure; DNA-binding; N ,N′-Bis(2-pyridyl)oxamide
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آدرس
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hubei key laboratory for processing and application of catalytic materials,huanggang normal university, China, school of mathematics and computer science,huanggang normal university, China, hubei key laboratory for processing and application of catalytic materials,huanggang normal university, China
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Authors
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