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Synthesis,characterization and biological screening of some new sulfonamides derivatives of 1,4-benzodioxane-6-amine
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نویسنده
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irshad m. ,abbasi m.a. ,rehman a.-u. ,siddiqui s.z. ,ashraf m. ,ejaz s.a. ,lodhi m.a. ,jamal s.b.
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منبع
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journal of the chemical society of pakistan - 2014 - دوره : 36 - شماره : 4 - صفحه:660 -673
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چکیده
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In the present study,a series of n-substituted derivatives of 1,4-benzodioxane-6-amine have been synthesized. the reaction of 1,4-benzodioxane-6-amine (1) with various alkyl/aryl sulfonyl chlorides (2a-k) yielded n-alkyl/aryl sulfonamides (3a-k),which further on treatment with benzyl chloride (4) in the presence of sodium hydride furnished into n-benzylated sulfonamides (6a-k) while the reaction of 3a-k with ethyl iodide (5 ) yielded n-ethylated sulfonamides 7a-k. these derivatives were characterized by ir,1h-nmr and ei-ms and then screened against acetylcholinesterase (ache),butyrylcholinesterase (bche) and lipoxygenase (lox) enzymes and were found to be good inhibitors of lipoxygenase only. the interaction between inhibitors and target enzymes were computationally observed which correlates with the experimental results.
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کلیدواژه
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1H-NMR; EI-MS; Enzymes; Inhibitors; IR; N-Substituted derivatives
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آدرس
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department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of chemistry,government college university, Pakistan, department of biochemistry and biotechnology,islamia university of bahawalpur, Pakistan, department of pharmacy,islamia university of bahawalpur, Pakistan, department of biochemistry,abdul wali khan university, Pakistan, department of bioinformatics,islamic international university, Pakistan
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Authors
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