Synthesis and Antimicrobial Evaluation of 6-Chloroquinolinylhydrazones and Acyclonucleosides of 7-Chloro-1,2,4-Triazolo[4,3-a]quinolines

Condensation of 6-chloro-2-hydrazinoquinoline (1) with monosaccharides 2a-e gave the corresponding sugar hydrazones 3a-e which upon acetylation gave the corresponding acetates 4f-j. cyclization of 3a-e using iron (iii) chloride afforded the acyclic nucleosides of triazoloquinolines sa-e which were also acetylated to give 6f-j. compound 1 was also condensed with aldehydes and isatin to give the corresponding hydrazones 7-10. reactions of 1 with etbylchloroformate. phthalic anhydride. acetyl acetone and tosyl chloride were also investigated. all compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria.