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Synthesis and molecular structures of 1-hydroxyethyl-2-(p-substituted) phenoxymethyl benzimidazoles
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نویسنده
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wu j. ,zhao l. ,zhao c. ,wang z. ,gu h. ,chen w.
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منبع
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journal of the chemical society of pakistan - 2016 - دوره : 38 - شماره : 5 - صفحه:974 -980
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چکیده
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Five novel 1-hydroxyethyl-2-(p-substituted) phenoxymethyl benzimidazoles were synthesized by a three-step route. under microwave irradiation,the p-substituted phenols were firstly o-carboxymethylated to prepare the corresponding p-substituted phenoxymethyl acids,which then reacted with o-phenylendiamine to get the key intermediates 2-(p-substituted) phenoxymethyl benzimidazole. finally,the solid-liquid phase transfer catalysis method,where tetrabutyl ammonium bromide (tbab) was used as the catalyst,was applied to synthesize the target compounds c1-c5 by the n-hydroxyethylation reaction with 2-chloroethyl alcohol. the structures of the obtained compounds were well characterized and confirmed by elemental analysis,ms,ir,1h nmr,13c nmr and single-crystal x-ray diffraction analysis. © 2016,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Benzimidazole; Crystal structures; N-hydroxyethylation; O-carboxymethylation; Synthesis
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آدرس
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key laboratory of leather chemistry and engineering of ministry of education,sichuan university,chengdu,china,national engineering laboratory for clean technology of leather manufacture,sichuan university,chengdu, China, key laboratory of leather chemistry and engineering of ministry of education,sichuan university,chengdu,china,national engineering laboratory for clean technology of leather manufacture,sichuan university,chengdu, China, college of bioengineering,sichuan university of science and engineering,zigong, China, key laboratory of leather chemistry and engineering of ministry of education,sichuan university,chengdu,china,national engineering laboratory for clean technology of leather manufacture,sichuan university,chengdu, China, key laboratory of leather chemistry and engineering of ministry of education,sichuan university,chengdu,china,national engineering laboratory for clean technology of leather manufacture,sichuan university,chengdu, China, key laboratory of leather chemistry and engineering of ministry of education,sichuan university,chengdu,china,national engineering laboratory for clean technology of leather manufacture,sichuan university,chengdu, China
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Authors
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