Structural characterization of inclusion complex of hesperidin methyl chalcone and hydroxypropyl-β-cyclodextrin

Hesperidin methyl chalcone (hmc) was a semisynthetic derivative of hesperidin,which owned antiviral and antimicrobial activities. owing these properties,it can be applied in pharmaceutical industry. however low stability had become a barrier to its application. in order to overcome this problem,an inclusion complex of hesperidin methyl chalcone and hydroxypropyl-β-cyclodextrin (hp-β-cd) were prepared by freeze-drying,using some analytical techniques to characterize the inclusion complex,including ultraviolet-visible spectroscopy (uv),fourier transform infrared spectroscopy (ft-ir),scanning electron microscopy (sem),x-ray diffractometry (xrd) and differential scanning calorimetry (dsc). the results of these analytical techniques indicated that the hesperidin methyl chalcone has been dispersed completely in the hp-β-cd without a new compound formed,but entrapped inside the cavity of hp-β-cd. © 2016,chemical society of pakistan. all rights reserved.