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Cytotoxic ceramides from Antipathes dichotoma
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نویسنده
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alarif w.m. ,al-lihaibi s.s. ,ayyad s.-e.n. ,ghandourah m.a. ,orif m.i. ,basaif s.a. ,abdel-lateff a.
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منبع
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journal of the chemical society of pakistan - 2016 - دوره : 38 - شماره : 3 - صفحه:553 -557
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چکیده
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A new ceramid (2s∗,3s∗,4e,8e)-2n-[hexadecanoyl]-4 (e),8 (e)-docosadiene-1,3-diol (1),along with the previously identified one (2s∗,3s∗,4e,8e)-2n-[tetradecanoyl]-4 (e),8 (e)-icosadiene-1,3-diol (2),and the dihydroxy steroid,24-methyl-cholest-5 (e),22 (e)-dien-3β,7α-diol (3) were identified from the red sea black coral antipathies dichotoma. extensive spectroscopic data 1d and 2d- nmr,uv,ir and ms were the bases for structure elucidation of all isolated metabolites. the spectral values for compound 3 are reported here for the first time. all compounds have been estimated toward their cytotoxicity,against several cancer cell lines; hepg2,wi 38,vero and mcf-7. they showed strong to moderate cytotoxic activities. compounds 1 and 2 displayed strong antiproliferative activities against hepg2 and mcf-7 cell lines. 3 displayed almost weak activity towards all investigated cell lines. © 2016,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Cytotoxicity; Spectroscopy; Sphingolipids; Steroids
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آدرس
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department of marine chemistry,faculty of marine sciences,king abdulaziz university,po. box 80207,jeddah, Saudi Arabia, department of marine chemistry,faculty of marine sciences,king abdulaziz university,po. box 80207,jeddah, Saudi Arabia, department chemistry,faculty of science,king abdulaziz university,po. box 80203,jeddah,saudi arabia,department of chemistry,faculty of science,damietta university,damietta, Egypt, department of marine chemistry,faculty of marine sciences,king abdulaziz university,po. box 80207,jeddah, Saudi Arabia, department of marine chemistry,faculty of marine sciences,king abdulaziz university,po. box 80207,jeddah, Saudi Arabia, department chemistry,faculty of science,king abdulaziz university,po. box 80203,jeddah, Saudi Arabia, department of natural products and alternative medicine,faculty of pharmacy,king abdulaziz university,po box 80260,jeddah,saudi arabia,department of pharmacognosy,faculty of pharmacy,minia university,minia, Egypt
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Authors
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