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Synthesis,characterization,crystal structures,analgesic and antioxidant activities of thiourea derivatives
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نویسنده
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shoaib m. ,shafiullah department of pharmacy ,ayaz m. ,tahir m.n. ,shah s.w.a.
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منبع
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journal of the chemical society of pakistan - 2016 - دوره : 38 - شماره : 3 - صفحه:479 -486
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چکیده
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1-(2-chlorobenzoyl)-3-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1h-pyrazol-4-yl)thiourea (cl2aap) and 1-(2-chlorobenzoyl)-3-(pyridine-2-yl)thiourea (cl2ap) were synthesized and characterized by spectroscopic methods (ft-ir,1h nmr) and single crystal x-ray diffraction. both compounds crystallized in monoclinic system and solved in p21/n,z = 4 and p21/c,z = 12 space groups respectively. pharmacological screenings of the synthesized compounds have shown comparable analgesic activity to that of the standard diclofenac sodium at 30 mg/kg body weight dose. the dpph and abts free radical scavenging activity of cl2aap are more significant than cl2ap as compared to standard (ic50= 10,60; 45,75; and <10 μg/ml for standard ascorbic acid respectively). © 2016,chemical society of pakistan. all rights reserved.
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کلیدواژه
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ABTS; Analgesic activity; Antioxident activity; DPPH; Thiourea derivatives; Writhing; XRD
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آدرس
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department of pharmacy,university of malakand,chakdara dir lower,khyber pakhtunkhwa, Pakistan, university of malakand,chakdara dir lower,khyber pakhtunkhwa, Pakistan, department of pharmacy,university of malakand,chakdara dir lower,khyber pakhtunkhwa, Pakistan, department of physics,university of sargodha,punjab, Pakistan, department of pharmacy,university of malakand,chakdara dir lower,khyber pakhtunkhwa, Pakistan
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Authors
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