Synthesis,characterization and antimicrobial evaluation of some thiazole-derived carbamates,semicarbazones,amides and carboxamide

This study comprises the synthesis and characterization of twenty thiazole-derived carbamates (3a-e),n-substituted amides (8a-h) and carboxamide (10) from 2-aminothiazoles (1a,b) via nucleophilic substitution reactions with activated carbonyl compounds including,chloroformates (2a-d),acid chlorides (7a-e) and glutaric anhydride (9),respectively. sequential hydrazinolysis of carbamate (3e) and condensation with a variety of aldehydes and ketones (5a-d) afforded the corresponding semicarbazones (6a-d). some selected synthesized compounds were subjected to in vitro antimicrobial evaluation against common pathogens including,gram+ve bacteria bacillus subtilis (nrrl b-543) and staphylococcus aureus,gram-ve bacteria escherichia coli (nrrlb-21),yeasts-candida albicans (nrrly-477) and saccharomyces cercvisiae (nrrl y-567) and fungs asperigillus niger (nrrl 599). screening results revealed that most of the tested compounds possess good antimicrobial activity compared to standard drugs. the highest inhibitory effects against gram-ve escherichia coli,gram+ve staphylococcus aureus,yeast candida albicans and fungus aspergillus niger was displayed by amide (8g) bearing the thiophene moiety. © 2016,chemical society of pakistan. all rights reserved.