Carbonic anhydrase and urease inhibition potential of soil borne fungi Screlotium rolfsii and Aspergillus flavus

The current study was aimed to evaluate the inhibitory activity of ethyl acetate and n-hexane fractions of screlotium rolfsii and aspergillus flavus against carbonic anhydrase-ii and urease enzymes. the etoac fraction from both fungal strains screlotium rolfsii and aspergillus flavus were found significantly active against carbonic anhydrase-ii with ic50 values of 45.40 ± 0.75 and 59.89 ± 1.65 respectively. similarly the n-hexane fraction of both fungi also showed significant result against carbonic anhydrase having ic50 values of 52.77 ± 0.81 and 61.3±1.75 respectively. the ethyl acetate and n-hexane fraction of both fungal strain did not shows significant results against urease enzyme inhibition studies and showed % inhibition less than 50. in conclusion,the crude extract and its fractions exhibited remarkable inhibition against carbonic anhydrase-ii. © 2017,chemical society of pakistan. all rights reserved.