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Design and anticancer evaluation of novel norcantharidin derivatives with 3D-QSAR studies
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نویسنده
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hu c. ,wang g. ,wu c. ,deng l.
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منبع
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journal of the chemical society of pakistan - 2017 - دوره : 39 - شماره : 2 - صفحه:261 -268
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چکیده
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Norcantharidin (nctd) is a demethylated form of cantharidin (can) which was discovered from traditional chinese medicine and is a treatment for cancers. in this study,two series of modification of can are designed and proposed based on the x-ray crystal structures of protein phosphatase 1 (pp1) and 2a (pp2a) which have been identified as molecular targets of can and nctd for the anticancer activities. the synthesized compounds were tested by in vitro assays to verify the anticancer efficacy. furthermore,the structure-activity relationship was discussed of the new efficacious compounds and their 3d-quantitative structure-activity relationship (3d-qsar) was employed for further investigation on potent target molecules. © 2017,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Anticancer evaluation; Aromatic amines; CoMFA; Norcantharidin derivatives
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آدرس
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department of chemistry and chemical engineering,shaoxing university,shaoxing, China, department of chemistry and chemical engineering,shaoxing university,shaoxing, China, department of chemistry and chemical engineering,shaoxing university,shaoxing, China, department of chemistry and chemical engineering,shaoxing university,shaoxing, China
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Authors
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