Synthesis of (E)-N′-[1-(2,4-dihydroxyphenyl)ethylidene]substituted hydrazides as possible α-glucosidase and butyrylcholinesterase inhibitors

In the current research work,(e)-n′-[1-(2,4-dihydroxyphenyl)ethylidene]substituted hydrazides were synthesized in a couple of steps and their enzyme inhibition potential was analyzed. firstly 2,4-hydroxyacetophenone (1) was reacted with hydrated hydrazine (2) under stirring to yield (e)-4-(1-hydrazonoethyl)benzene-1,3-diol (3) which was further reacted with different acid halides,(4a-i) to afford (e)-[1-(2,4-dihydroxyphenyl)ethylidene]substituted hydrazides (5a-i). these synthesized compounds were characterized by ei-ms,1h-nmr spectral techniques and were also evaluated against α-glucosidase and butyrylcholinesterase enzymes. the synthesized compounds were found to be acceptable inhibitors of α-glucosidase and decent inhibition against butyrylcholinesterase. © 2017,chemical society of pakistan. all rights reserved.