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Anti-leishmanial activities of synthetic biscoumarins
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نویسنده
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rahim f. ,samreen h. e. j. research institute of chemistry ,ullah h. ,fakhri m.i. ,salar u. ,perveen s. ,khan k.m. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2017 - دوره : 39 - شماره : 1 - صفحه:79 -82
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چکیده
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Synthetic biscoumarins 1-19 were screened to check their anti-leishmanial activity. out of nineteen,analogs 2 (ic50 = 46.95 ± 1.23 μm),4 (ic50 = 63.03 ± 0.20 μm),5 (ic50 = 41.35 ± 0.51 μm),6 (ic50 = 35.62 ± 0.15 μm),7 (ic50 = 75.35 ± 0.35 μm),10 (ic50 = 82.36 ± 1.93 μm),11 (ic50 = 76.45 ± 0.13 μm),16 (ic50 = 59.21 ± 1.00 μm),18 (ic50 = 75.73 ± 1.54 μm),and 19 (ic50 = 76.43 ± 0.04 μm) exhibited moderate to weak anti-leishmanial potential,if compared with the standard pentamidine (ic50 = 5.09 ± 0.04 μm),whilst rest of the analogs were found to be inactive. © 2017,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Anti-leishmanial activities; Biscoumarins; In vitro; Pentamidine; Synthesis
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آدرس
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department of chemistry,hazara university,mansehra,khyber pukhtunkhwa, Pakistan, international center for chemical and biological sciences,university of karachi,karachi, Pakistan, department of chemistry,hazara university,mansehra,khyber pukhtunkhwa, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi, Pakistan, pcsir laboratories complex,karachi,shahrah-e-dr. salimuzzaman siddiqui,karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi,pakistan,department of biochemistry,faculty of science,king abdulaziz university,jeddah, Saudi Arabia
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Authors
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rahim ,samreen ,ullah ,fakhri ,salar ,perveen ,khan ,choudhary
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