Aervfuranoside: A new chlorinated dibenzofuran glycoside and other metabolites from the flowers of aerva javanica

Aervfuranoside (1),a new chlorinated dibenzofuran glycoside together with ten (2-11) known compounds were isolated from ethyl acetate soluble fraction of methanolic extract of the flowers of aerva javanica. the structures of isolates were elucidated by the combination of 1d (1h and 13c-nmr),2d (hmqc,hmbc and cosy) nmr spectroscopy and mass spectrometry (fabms,hrfabms) or in comparison with the literature data in case of known metabolites. among these isolates,only compounds 1-3 were evaluated for dpph free radical scavenging potential and enzyme inhibitory activity against acetylcholinesterase (ache),butyrylcholinesterase (bche),lipoxygenase (lox) and metallo-β-lactamase (imp-1). the test compound 2 exhibited moderate inhibition of the enzyme lipoxygenase with the ic50 value of 53.5 μm.