Synthesis of a new heteroleptic copper(II) complex: Structural elucidation,DNA binding and in-vitro alpha glucosidase inhibition studies

Summary: a new dimeric heteroleptic cu(ii) complex with formula [cu2(2-ch3-3-no2c6h3ch2coo)4(2-cl-py)2],where cl-py = 2-chloropyridine,has been synthesized and characterized by ft-ir,uv-visible spectroscopy and single crystal xrd. the single crystal xrd revealed that the complex crystallized in monoclinic space group p2/n with square pyramidal geometry around each copper atom and adopted paddlewheel conformation with cu….cu intra-dimer distance of 2.66 å. the dna binding studies of the complex were carried out through uv-visible spectroscopy where a high value of the binding constant (kb = 1.51 × 104 m-1) suggested its strong affinity towards dna molecule. moreover,in-vitro ?-glucosidase inhibition assay of the complex with acarbose as control revealed its anti-diabetic potential with ic50 value of 13.1 ?m.