Synthesis and biological significances of new heterocyclic compounds containing 5-(4-chlorobenzyl)-3-(4-chlorophenyl)-1H-1,2,4-Triazol ring

In this study,some novel 5-(4-chlorobenzyl)-3-(4-chlorophenyl)-1h-1,2,4-triazol derivatives were synthesized starting from 4-amino-3-(4-chlorobenzyl)-5-(4-chlorophenyl)-4h- 1,2,4-triazole (1). the structures of the synthesized compounds were clarified using ir,1h nmr,13c nmr,elemental analyses and mass spectral techniques. the synthesized compounds were tested for antimicrobial and anti-lipase inhibitory activities. among the tested substances,compounds 3,8c,8d,8e and 9d exhibited good activity against gram-positive bacteria. furthermore,all the synthesized compounds were investigated with regard to pancreatic lipase inhibition activity,and compounds 5e,8b,and 9b showed a considerable anti-lipase activity at various concentrations. © chemical society of pakistan. all right reserved.